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During the events of The New Atlantis, the campaign from The Titans expansion, Kronos uses his servant, disguised as Krios the theocrat, to open one of the gates. He succeeds, but is sent back to Tartarus by his mother, Gaia.
In Greek Mythology, Tartarus is the most unforgiving part of the Underworld, as it is a deep abyss reserved for endless torment and suffering of the wicked, as well as being a prison for the Titans.