"Cherokee literacy lets Cherokee villagers work closely with you. You get a shipment of four Settlers."—In-game description
Sequoyah's Cherokee Syllabary is a technology in Age of Empires III that can be researched at a Trading Post built on a Cherokee settlement. Once researched, four Settlers will appear in the player's Home City shipment point.
Sequoyah's Cherokee Syllabary is best used after Revolution for European civilizations to keep a small economy running and rebuilding lost structures, and can be useful for the Chinese if they are allied with the Russians and have sent the Blockhouse Wagon shipment, which allows them to build additional Blockhouses.