Kanyenke is a proud Mohwak warrior of the Iroquois. Smart, savvy and strong, he is a master at using a bow for ranged attacks and delivers a lethal, lightning-fast swipe with his tomahawk at close combat. As John Black's faithful friend and ally, Kanyenke has fought fierce battles and eluded dangers alongside Black to share the spoils from many victories.
In 1757, Morgan's grandson, John Black, and his Native friend Kanyenke are on their way to Brunswick, Black's uncle Stuart’s colony, as he has called for help. After exchanging attacks with Cherokee raiders and war camps, they attempt to arrange a peace settlement. When they reach the village, they are attacked by the British who capture the town. While planning a counter attack, they discover that John's uncle Stuart has been kidnapped; John concludes that the Circle of Ossus has returned. Kanyenke realizes that his sister, Nonahkee is in danger, too; but he is stunned to discover, after saving the Iroquois village in New England that she called home, that she and John were secretly in love. Afterwards Kanyenke consents to their love and joins John in taking down the Circle.
They fight with the French in the Seven Years' War. When Colonel Washington tells them that Warwick is a renegade, John agrees to track him down for the British. John leads his mercenaries and Washington's forces and destroy a Circle base in the Great Lakes. Warwick, the Circle's leader, is revealed to have killed Stuart, and flees to the western mountains. John and Kanyenke follow him, first earning the respect of the Great Plains tribes by gaining enormous amounts of experience from good deeds, then destroying a fortified Circle base in the mountains. They soon discover that Warwick and his soldiers have fled west, to act as a checkpoint for a Russian army. They realize that the Circle plans to capture British and French colonies and towns while their soldiers are at war with one another. With the help of some miners, they were able to bring down large rock bridges to stop the Russian large cannons from getting through. In the end John is shown setting up some dynamite. Warwick and several Circle soldiers approach him. Warwick attempts to kill John but when the Circle soldiers shoot at him, John dodges the bullets, jumps to the trigger, and pushes it, detonating the bridge, killing himself, the soldiers, and Warwick, and causing an avalanche. The avalanche buries the Russians. Kanyenke returns to his village, where he learns that his sister had given birth to John's son Nathaniel.
Then in Act Three, Steel, Kanyenke was watching Pierre Beaumont and Amelia Black going to the Caves in a Mountain Pass, revealing that Beaumont is the New Leader of the Circle of Ossus, Pierre then said he fallowed him for too long but Kanyenke had Cooper and Hussars with him. Then Kanyenke helps Amelia throughout the rest of Act Three..later as Kanyenke and Amelia destroy the Ossuary, Their Troops rush in, Beaumont gets a broken leg, then he tackles Kanyenke, then Beaumont kicks Amelia away, making her drop her Shotgun, Beaumont then rushes at Amelia, but he fails in killing her as he gets shot by her Shotgun, the Circle's stolen treasure then become part of the Falcon Company's Wealth.
It is unknown when Kayenke died.